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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs.

Authors: Li, Hao; Ranhotra, Harmit S; Mani, Sridhar; Dvořák, Zdeněk; Sokol, Harry; Müller, Rolf

Published In Drug Discov Today, (2020 Sep)

Abstract: The concept of small-molecule mimicry even of weak microbial metabolites present in rodents and humans, as a means to expand drug repertoires, is new. Hitherto, there are few proof-of-concept papers demonstrating utility of this concept. More recently, papers demonstrating mimicry of intestinal microbial metabolites could expand the drug repertoire for diseases such as inflammatory bowel disease (IBD). We opine that, as more functional metabolite-receptor pairings are discovered, small-molecule metabolite mimicry could be a significant effort in drug discovery.

PubMed ID: 32562605 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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