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Your Environment. Your Health.

Publication Detail

Title: An introduction for the special issue on environmental health and genome integrity.

Authors: Yan, Shan; Vaziri, Cyrus

Published In Environ Mol Mutagen, (2020 08)

Abstract: Environmental exposures and genome maintenance mechanisms that respond to environmentally-induced genotoxicity have a profound impact on human health. Eight review articles in this Special Issue (SI) titled "Environmental Health and Genome Integrity" describe emerging new mechanisms by which distinct forms of environmentally-induced DNA damage are remediated, and explain how DNA repair pathway choices impact genome integrity and disease propensity. Here, we provide an introduction to reviews from this SI. Our expanding knowledge of how genotoxic exposures impact the genome will allow us to better predict, prevent and treat environmentally-induced human diseases such as cancer and neurodegenerative disorders.

PubMed ID: 32683747 Exiting the NIEHS site

MeSH Terms: Animals; DNA Damage/genetics; DNA Repair/genetics; Environmental Exposure/adverse effects*; Environmental Health/methods; Genome/genetics*; Humans; Neoplasms/genetics; Neurodegenerative Diseases/genetics

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