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Publication Detail

Title: Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children.

Authors: Rahbar, Mohammad H; Samms-Vaughan, Maureen; Saroukhani, Sepideh; Lee, MinJae; Zhang, Jing; Bressler, Jan; Hessabi, Manouchehr; Shakespeare-Pellington, Sydonnie; Grove, Megan L; Loveland, Katherine A

Published In J Autism Dev Disord, (2021 Jun)

Abstract: Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.

PubMed ID: 32892263 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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