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Publication Detail

Title: A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta.

Authors: Eaves, Lauren; Phookphan, Preeyaphan; Rager, Julia; Bangma, Jacqueline; Santos Jr, Hudson P; Smeester, Lisa; O'Shea, Thomas Michael; Fry, Rebecca

Published In Epigenomics, (2020 09)

Abstract: Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequencing. Differential expression analysis was used to identify differences in the expression based on the sex of the fetus. Results: Sexually dimorphic expression was observed for 128 mRNAs and 59 miRNAs. A set of 25 miRNA master regulators was identified that likely contribute to the sexual dimorphic mRNA expression. Conclusion: These data highlight sex-dependent miRNA and mRNA patterning in the placenta and provide insight into a potential mechanism for observed sex differences in outcomes.

PubMed ID: 32901510 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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