Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.

Authors: Beecher, Maria; Kumar, Namrata; Jang, Sunbok; Rapić-Otrin, Vesna; Van Houten, Bennett

Published In DNA Repair (Amst), (2020 10)

Abstract: UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledge of the structure and function of this intriguing repair protein. Finally, this article discusses emerging data suggesting that UV-DDB may have other non-canonical roles in base excision repair and the etiology of cancer.

PubMed ID: 32739133 Exiting the NIEHS site

MeSH Terms: DNA Repair*; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism*; Genomic Instability; Humans; Mutation; Neoplasms/genetics; Neoplasms/metabolism

Back
to Top