Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.

Authors: Tu, Maolin; Wang, Weicang; Zhang, Guodong; Hammock, Bruce D

Published In Nutrients, (2020 Oct 28)

Abstract: Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations. In this review, we summarize recent studies of ω-3 PUFAs on colonic inflammation and CRC and discuss the potential roles of ω-3 PUFA-metabolizing enzymes, notably the cytochrome P450 monooxygenases, in mediating the actions of ω-3 PUFAs.

PubMed ID: 33126566 Exiting the NIEHS site

MeSH Terms: Animals; Anti-Inflammatory Agents/pharmacology*; Antineoplastic Agents/pharmacology*; Colitis/prevention & control*; Colon/drug effects; Colorectal Neoplasms/prevention & control*; Cytochrome P-450 Enzyme System/metabolism; Epoxide Hydrolases/metabolism; Fatty Acids, Omega-3/pharmacology*; Humans; Mixed Function Oxygenases/metabolism

Back
to Top