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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.

Authors: Tu, Maolin; Wang, Weicang; Zhang, Guodong; Hammock, Bruce D

Published In Nutrients, (2020 Oct 28)

Abstract: Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations. In this review, we summarize recent studies of ω-3 PUFAs on colonic inflammation and CRC and discuss the potential roles of ω-3 PUFA-metabolizing enzymes, notably the cytochrome P450 monooxygenases, in mediating the actions of ω-3 PUFAs.

PubMed ID: 33126566 Exiting the NIEHS site

MeSH Terms: Animals; Anti-Inflammatory Agents/pharmacology*; Antineoplastic Agents/pharmacology*; Colitis/prevention & control*; Colon/drug effects; Colorectal Neoplasms/prevention & control*; Cytochrome P-450 Enzyme System/metabolism; Epoxide Hydrolases/metabolism; Fatty Acids, Omega-3/pharmacology*; Humans; Mixed Function Oxygenases/metabolism

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