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National Institute of Environmental Health Sciences

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Publication Detail

Title: Manganese: recent advances in understanding its transport and neurotoxicity.

Authors: Aschner, Michael; Guilarte, Tomás R; Schneider, Jay S; Zheng, Wei

Published In Toxicol Appl Pharmacol, (2007 Jun 01)

Abstract: The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

PubMed ID: 17466353 Exiting the NIEHS site

MeSH Terms: Animals; Behavior, Animal/drug effects; Biological Transport; Brain/diagnostic imaging; Brain/drug effects; Manganese/pharmacokinetics*; Manganese/toxicity*; Positron-Emission Tomography; Primates

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