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National Institute of Environmental Health Sciences

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Publication Detail

Title: Human DNA ligases in replication and repair.

Authors: Sallmyr, Annahita; Rashid, Ishtiaque; Bhandari, Seema Khattri; Naila, Tasmin; Tomkinson, Alan E

Published In DNA Repair (Amst), (2020 09)

Abstract: To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases encoded by three genes, LIG1, LIG3 and LIG4. Mutations in LIG1 and LIG4 have been identified as the causative factor in two inherited immunodeficiency syndromes. Moreover, there is emerging evidence that DNA ligases may be good targets for the development of novel anti-cancer agents. In this graphical review, we provide an overview of the roles of the DNA ligases encoded by the three human LIG genes in DNA replication and repair.

PubMed ID: 33087274 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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