Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Metabolism of Inorganic Arsenic in Mice Lacking Genes Encoding GST-P, GST-M, and GST-T.

Authors: Douillet, Christelle; Koller, Beverly H; Stýblo, Miroslav

Published In Chem Res Toxicol, (2020 08 17)

Abstract: To investigate the role of glutathione transferases (GSTs) in the metabolism of inorganic arsenic (iAs), we compared the disposition of iAs and its metabolites in wild-type mice and mice lacking genes encoding GST-P, -M and -T after exposure to 100 ppb iAs in drinking water. We found no differences between the two genotypes in the concentrations of total arsenic or arsenic species in urine, liver, and kidneys. No genotype-dependent differences were found in proportions of arsenicals in the tissues, and only small differences were observed in the urine. Thus, under these conditions, GST-P, -M and -T did not play a significant role in iAs metabolism in mice.

PubMed ID: 32700902 Exiting the NIEHS site

MeSH Terms: Animals; Arsenic/administration & dosage; Arsenic/analysis; Arsenic/metabolism*; Drinking Water/administration & dosage; Drinking Water/analysis; Drinking Water/metabolism; Environmental Exposure/analysis; Glutathione Transferase/genetics; Glutathione Transferase/metabolism; Mice

Back
to Top