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Publication Detail

Title: Regulation and pharmacological targeting of RAD51 in cancer.

Authors: Grundy, McKenzie K; Buckanovich, Ronald J; Bernstein, Kara A

Published In NAR Cancer, (2020 Sep)

Abstract: Regulation of homologous recombination (HR) is central for cancer prevention. However, too little HR can increase cancer incidence, whereas too much HR can drive cancer resistance to therapy. Importantly, therapeutics targeting HR deficiency have demonstrated a profound efficacy in the clinic improving patient outcomes, particularly for breast and ovarian cancer. RAD51 is central to DNA damage repair in the HR pathway. As such, understanding the function and regulation of RAD51 is essential for cancer biology. This review will focus on the role of RAD51 in cancer and beyond and how modulation of its function can be exploited as a cancer therapeutic.

PubMed ID: 33015624 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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