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Publication Detail

Title: The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage.

Authors: Kumar, Namrata; Raja, Sripriya; Van Houten, Bennett

Published In Nucleic Acids Res, (2020 11 18)

Abstract: The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways. In particular, several studies have demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative manner in the removal of oxidative lesions. This review focuses on recent data showing how the NER proteins, XPA, XPC, XPG, CSA, CSB and UV-DDB, work to stimulate known glycosylases involved in the removal of certain forms of base damage resulting from oxidative processes, and also discusses how some oxidative lesions are probably directly repaired through NER. Finally, since many glycosylases are inhibited from working on damage in the context of chromatin, we detail how we believe UV-DDB may be the first responder in altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.

PubMed ID: 33010169 Exiting the NIEHS site

MeSH Terms: 5-Methylcytosine/metabolism; DNA Damage; DNA Repair/genetics*; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism*; Guanine/analogs & derivatives; Guanine/metabolism; Humans; Oxidation-Reduction; Oxidative Stress/genetics*; Thymine/analogs & derivatives; Thymine/metabolism; Xeroderma Pigmentosum/genetics; Xeroderma Pigmentosum/metabolism*

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