Title: Maternal lipodome across pregnancy is associated with the neonatal DNA methylome.

Authors: LaBarre, Jennifer L; McCabe, Carolyn F; Jones, Tamara R; Song, Peter Xk; Domino, Steven E; Treadwell, Marjorie C; Dolinoy, Dana C; Padmanabhan, Vasantha; Burant, Charles F; Goodrich, Jaclyn M

Published In Epigenomics, (2020 12)

Abstract: Aim: To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Materials & methods: Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. Results: M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. Conclusion: The maternal lipidome may be influential in establishing the infant epigenome.

PubMed ID: 33290095

MeSH Terms: Adult; CpG Islands; DNA Methylation*; Epigenome*; Female; Fetal Blood/immunology; Humans; Infant, Newborn; Leukocyte Count; Lipid Metabolism; Lipids/blood*; Male; Middle Aged; Pregnancy/blood*