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Title: Tuning T helper cell differentiation by ITK.

Authors: Elmore, Jessica P; McGee, Michael C; Nidetz, Natalie F; Anannya, Orchi; Huang, Weishan; August, Avery

Published In Biochem Soc Trans, (2020 02 28)

Abstract: CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.

PubMed ID: 32049330 Exiting the NIEHS site

MeSH Terms: Animals; Cell Differentiation/immunology*; Cytokines/metabolism; Forkhead Transcription Factors/metabolism; Humans; Lymphocyte Activation/immunology; Mice; Protein-Tyrosine Kinases/immunology*; Protein-Tyrosine Kinases/metabolism; Receptors, Antigen, T-Cell/metabolism; Signal Transduction/immunology; T-Lymphocytes, Regulatory/immunology; Th17 Cells/immunology*; Th17 Cells/metabolism

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