Title: Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Authors: Chang, Chun-Pin; La Vecchia, Carlo; Serraino, Diego; Olshan, Andrew F; Zevallos, Jose P; Morgenstern, Hal; Levi, Fabio; Garavello, Werner; Kelsey, Karl; McClean, Michael; Chen, Chu; Schwartz, Stephen M; Schantz, Stimson; Yu, Guo-Pei; Boffetta, Paolo; Hashibe, Mia; Lee, Yuan-Chin Amy; Parpinel, Maria; Augustin, Livia S A; Turati, Federica; Zhang, Zuo-Feng; Edefonti, Valeria

Published In Br J Cancer, (2020 03)

Abstract: High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

PubMed ID: 31929514

MeSH Terms: No MeSH terms associated with this publication