Title: Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.
Authors: Maguire, Rachel L; House, John S; Lloyd, Dillon T; Skinner, Harlyn G; Allen, Terrence K; Raffi, Asifa Mohamed; Skaar, David A; Park, Sarah S; McCullough, Lauren E; Kollins, Scott H; Bilbo, Staci D; Collier, David N; Murphy, Susan K; Fuemmeler, Bernard F; Gowdy, Kymberly M; Hoyo, Cathrine
Published In Pediatr Obes, (2021 07)
Abstract: BACKGROUND: Although maternal systemic inflammation is hypothesized to link maternal pre-pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. OBJECTIVES: In this study, we hypothesized that pre-pregnancy obesity alters systemic chemo/cytokines concentrations in pregnancy, and this alteration contributes to obesity in children. METHODS: In a multi-ethnic cohort of 361 mother-child pairs, we measured prenatal concentrations of plasma TNF-α, IL-6, IL-8, IL-1β, IL-4, IFN-γ, IL-12 p70 subunit, and IL-17A using a multiplex ELISA and examined associations of pre-pregnancy obesity on maternal chemo/cytokine levels, and associations of these cytokine levels with offspring body mass index z score (BMI-z) at age 2-6 years using linear regression. RESULTS: After adjusting for maternal smoking, ethnicity, age, and education, pre-pregnancy obesity was associated with increased concentrations of TNF-α (P = .026) and IFN-γ (P = .06). While we found no evidence for associations between TNF-α concentrations and offspring BMI-z, increased IFN-γ concentrations were associated with decreased BMI-z (P = .0002), primarily in Whites (P = .0011). In addition, increased maternal IL-17A concentrations were associated with increased BMI-z in offspring (P = .0005) with stronger associations in African Americans (P = .0042) than Whites (P = .24). CONCLUSIONS: Data from this study are consistent with maternal obesity-related inflammation during pregnancy, increasing the risk of childhood obesity in an ethnic-specific manner.
PubMed ID: 33381912
MeSH Terms: No MeSH terms associated with this publication