Title: Extracellular vesicles and female reproduction.
Authors: Machtinger, Ronit; Baccarelli, Andrea A; Wu, Haotian
Published In J Assist Reprod Genet, (2021 Mar)
Abstract: Extracellular vesicles (EVs) are nano-sized membrane bound complexes that have been identified as a mean for intercellular communication between cells and tissues both in physiological and pathological conditions. These vesicles contain numerous molecules involved in signal transduction including microRNAs, mRNAs, DNA, proteins, lipids, and cytokines and can affect the behavior of recipient cells. Female reproduction is dependent on extremely fine-tuned endocrine regulation, and EVs may represent an added layer that contributes to this regulation. This narrative review article provides an update on the research of the role of EVs in female reproduction including folliculogenesis, fertilization, embryo quality, and implantation. We also highlight potential pitfalls in typical EV studies and discuss gaps in the current literature.
PubMed ID: 33471231
MeSH Terms: Embryo Implantation*; Extracellular Vesicles/genetics; Extracellular Vesicles/metabolism*; Female; Humans; Ovarian Follicle/cytology; Ovarian Follicle/physiology*; Reproduction*