Title: Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.

Authors: Sun, Cheng-Peng; Zhang, Xin-Yue; Morisseau, Christophe; Hwang, Sung Hee; Zhang, Zhan-Jun; Hammock, Bruce D; Ma, Xiao-Chi

Published In J Med Chem, (2021 01 14)

Abstract: Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. Therefore, since the beginning of this century, the development of sEH inhibitors is a hot research topic. A variety of potent sEH inhibitors have been developed by chemical synthesis or isolated from natural sources. In this review, we mainly summarized the interconnected aspects of sEH with cardiovascular, central nervous system, and metabolic diseases and then focus on representative inhibitors, which would provide some useful guidance for the future development of potential sEH inhibitors.

PubMed ID: 33369424

MeSH Terms: Animals; Biological Products/chemistry*; Drug Discovery*; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/isolation & purification; Enzyme Inhibitors/pharmacology*; Epoxide Hydrolases/antagonists & inhibitors*; Epoxide Hydrolases/chemistry; Humans; Molecular Structure; Solubility