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Publication Detail

Title: Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10-/- Mice.

Authors: Xie, Minhao; Yang, Jun; Zhang, Jianan; Sherman, Heather L; Zhang, Zhenyu; Minter, Lisa M; Hammock, Bruce D; Park, Yeonhwa; Zhang, Guodong

Published In J Agric Food Chem, (2020 Jul 22)

Abstract: Dietary intake of linoleic acid (LA, 18:2ω-6) has risen dramatically in recent decades. Previous studies have suggested a high intake of LA could increase tissue concentrations of proinflammatory and protumorigenic ω-6-series eicosanoid metabolites, increasing risks of inflammation and associated diseases. However, the effects of a LA-rich diet on in vivo profiles of eicosanoids and development of inflammatory diseases are understudied. Here, we treated spontaneous colitis-prone (Il-10-/-) mice with a control diet (∼3 Cal% LA) or a LA-rich diet (∼9 Cal% LA) for 18 weeks and analyzed the effects of the LA-rich diet on profiles of eicosanoids and development of colitis. We found that treatment with the LA-rich diet increased the tissue level of LA: the liver levels of LA were 5.8 ± 0.6% in the control diet-treated mice versus 11.7 ± 0.7% in the LA-rich diet-treated mice (P < 0.01). The plasma concentrations of a series of LA-derived metabolites, including 9-hydroxyoctadecadienoic acid (HODE), 9,10-dihydroxyoctadecenoic acid (DiHOME), 12,13-DiHOME, and 13-HODE were significantly increased by treatment with the LA-rich diet (P < 0.05). However, the LA-rich diet had little effect on the severity of colitis in the treated Il-10-/- mice. These results suggest a limited role of increased consumption of dietary LA on promoting colitis in the Il-10-/- model.

PubMed ID: 32594738 Exiting the NIEHS site

MeSH Terms: Animals; Colitis/blood*; Colitis/diet therapy*; Colitis/genetics; Eicosanoids/blood*; Humans; Interleukin-10/deficiency*; Interleukin-10/genetics; Linoleic Acid/chemistry; Linoleic Acid/metabolism*; Liver/metabolism; Male; Mice; Mice, Knockout

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