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Title: Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School-Age Children.

Authors: Silva, Carolina C V; Jaddoe, Vincent W V; Sol, Chalana M; El Marroun, Hanan; Martinez-Moral, Maria-Pilar; Kannan, Kurunthachalam; Trasande, Leonardo; Santos, Susana

Published In Obesity (Silver Spring), (2021 02)

Abstract: OBJECTIVE: The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. METHODS: Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. RESULTS: An interquartile range increase in di-n-octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87, and 1.43; 95% CI: 1.09-1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in high-density lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years (P < 0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years (P < 0.01). CONCLUSIONS: DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.

PubMed ID: 33491307 Exiting the NIEHS site

MeSH Terms: Adipose Tissue/chemistry*; Benzhydryl Compounds/urine*; Blood Glucose/analysis; Blood Pressure/physiology; Body Mass Index*; Child; Heart Disease Risk Factors; Humans; Netherlands; Overweight/epidemiology; Phenols/urine*; Phthalic Acids/urine*

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