Title: XIAP's Profile in Human Cancer.
Authors: Tu, Huailu; Costa, Max
Published In Biomolecules, (2020 10 29)
Abstract: XIAP, the X-linked inhibitor of apoptosis protein, regulates cell death signaling pathways through binding and inhibiting caspases. Mounting experimental research associated with XIAP has shown it to be a master regulator of cell death not only in apoptosis, but also in autophagy and necroptosis. As a vital decider on cell survival, XIAP is involved in the regulation of cancer initiation, promotion and progression. XIAP up-regulation occurs in many human diseases, resulting in a series of undesired effects such as raising the cellular tolerance to genetic lesions, inflammation and cytotoxicity. Hence, anti-tumor drugs targeting XIAP have become an important focus for cancer therapy research. RNA-XIAP interaction is a focus, which has enriched the general profile of XIAP regulation in human cancer. In this review, the basic functions of XIAP, its regulatory role in cancer, anti-XIAP drugs and recent findings about RNA-XIAP interactions are discussed.
PubMed ID: 33138314
MeSH Terms: Apoptosis/genetics; Carcinogenesis/genetics*; Disease Progression; Humans; Neoplasms/genetics*; Neoplasms/pathology; Neoplasms/therapy; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein/genetics*