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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Disposition of PCB 11 in Mice Following Acute Oral Exposure.

Authors: Zhang, Chun-Yun; Klocke, Carolyn R; Lein, Pamela J; Lehmler, Hans-Joachim

Published In Chem Res Toxicol, (2021 04 19)

Abstract: PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼ muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.

PubMed ID: 33734669 Exiting the NIEHS site

MeSH Terms: Animals; Mice; Molecular Structure; Polychlorinated Biphenyls/administration & dosage; Polychlorinated Biphenyls/chemistry; Polychlorinated Biphenyls/metabolism*

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