Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice.

Authors: Fields, Ashley M; Welle, Kevin; Ho, Elaine S; Mesaros, Clementina; Susiarjo, Martha

Published In Commun Biol, (2021 03 26)

Abstract: In pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell number, impaired insulin secretion, and gestational glucose intolerance in mice. Albeit the tryptophan-serotonin pathway is dependent on vitamin B6 bioavailability, how vitamin B6 deficiency impacts β-cell proliferation during pregnancy has not been investigated. In this study, we created a vitamin B6 deficient mouse model and investigated how gestational deficiency influences maternal glucose tolerance. Our studies show that gestational vitamin B6 deficiency decreases serotonin levels in maternal pancreatic islets and reduces β-cell proliferation in an HTR2B-dependent manner. These changes were associated with glucose intolerance and insulin resistance, however insulin secretion remained intact. Our findings suggest that vitamin B6 deficiency-induced gestational glucose intolerance involves additional mechanisms that are complex and insulin independent.

PubMed ID: 33772108 Exiting the NIEHS site

MeSH Terms: Animals; Diabetes, Gestational/etiology; Diabetes, Gestational/physiopathology*; Disease Models, Animal; Female; Insulin-Secreting Cells/physiology*; Islets of Langerhans/physiology*; Mice; Mice, Inbred C57BL; Pregnancy; Serotonin/physiology*; Signal Transduction*; Vitamin B 6 Deficiency/physiopathology*

Back
to Top