Skip Navigation

Publication Detail

Title: Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma.

Authors: Czyzyk-Krzeska, Maria F; Landero Figueroa, Julio A; Gulati, Shuchi; Cunningham, John T; Meller, Jarek; ShamsaeI, Behrouz; Vemuri, Bhargav; Plas, David R

Published In Genes (Basel), (2021 03 09)

Abstract: The promise of personalized medicine is a therapeutic advance where tumor signatures obtained from different omics platforms, such as genomics, transcriptomics, proteomics, and metabolomics, in addition to environmental factors including metals and metalloids, are used to guide the treatments. Clear cell renal carcinoma (ccRCC), the most common type of kidney cancer, can be sporadic (frequently) or genetic (rare), both characterized by loss of the von Hippel-Lindau (VHL) gene that controls hypoxia inducible factors. Recently, several genomic subtypes were identified with different prognoses. Transcriptomics, proteomics, metabolomics and metallomic data converge on altered metabolism as the principal feature of the disease. However, in view of multiple biochemical alterations and high level of tumor heterogeneity, identification of clearly defined subtypes is necessary for further improvement of treatments. In the future, single-cell combined multi-omics approaches will be the next generation of analyses gaining deeper insights into ccRCC progression and allowing for design of specific signatures, with better prognostic/predictive clinical applications.

PubMed ID: 33803184 Exiting the NIEHS site

MeSH Terms: Animals; Carcinoma, Renal Cell/genetics; Carcinoma, Renal Cell/metabolism*; Gene Expression Profiling/methods; Gene Expression Regulation, Neoplastic/genetics; Humans; Kidney Neoplasms/genetics; Kidney Neoplasms/metabolism*; Precision Medicine; Prognosis; Transcriptome/genetics

Back
to Top
Last Reviewed: October 07, 2024