Title: Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study.

Authors: Sol, Chalana M; Santos, Susana; Duijts, Liesbeth; Asimakopoulos, Alexandros G; Martinez-Moral, Maria-Pilar; Kannan, Kurunthachalam; Philips, Elise M; Trasande, Leonardo; Jaddoe, Vincent W V

Published In Int J Obes (Lond), (2020 11)

Abstract: OBJECTIVES: Fetal exposure to phthalates and bisphenols might have long-lasting effects on growth and fat development. Not much is known about the effects on general and organ fat development in childhood. We assessed the associations of fetal exposure to phthalates and bisphenols with general and organ fat measures in school-aged children. METHODS: In a population-based, prospective cohort study among 1128 mother-child pairs, we measured maternal urinary phthalate metabolites and bisphenol concentrations in first, second, and third trimester. Offspring body mass index, fat mass index by dual-energy X-ray absorptiometry, and visceral and pericardial fat indices and liver fat fraction were measured by magnetic resonance imaging at 10 years. RESULTS: After adjustment for confounders and correction for multiple testing, an interquartile range increase in first trimester phthalic acid concentrations remained associated with a 0.14 (95% confidence interval: 0.05, 0.22) standard deviation score increase in pericardial fat index. We also observed tendencies for associations of higher maternal low molecular weight phthalate urinary concentrations in second trimester with childhood pericardial fat index, but these were not significant after adjustment for multiple testing. High molecular weight phthalate, di-2-ethylhexyl phthalate, and di-n-octyl phthalate concentrations were not associated with childhood outcomes. Maternal urinary bisphenol concentrations were not associated with childhood adiposity. CONCLUSIONS: Maternal first trimester phthalic acid concentrations are associated with increased childhood pericardial fat index at 10 years of age, whereas maternal bisphenol concentrations are not associated with childhood adiposity. We did not find significant sex-specific effects. These findings should be considered as hypothesis generating and need further replication and identification of underlying mechanisms.

PubMed ID: 32920592

MeSH Terms: Adiposity*; Adult; Benzhydryl Compounds/urine*; Body Mass Index*; Child; Female; Humans; Male; Maternal Exposure/adverse effects*; Netherlands; Pediatric Obesity/epidemiology; Pericardium; Phenols/urine*; Phthalic Acids/urine*; Pregnancy; Prospective Studies