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Publication Detail

Title: Mechanisms of enhancer action: the known and the unknown.

Authors: Panigrahi, Anil; O'Malley, Bert W

Published In Genome Biol, (2021 04 15)

Abstract: Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential gene expression programs are the enhancers, the gene-distal cis-regulatory sequences that govern spatiotemporal and quantitative expression dynamics of target genes. Enhancers are widely believed to physically contact the target promoters to effect transcriptional activation. However, our understanding of the full complement of regulatory proteins and the definitive mechanics of enhancer action is incomplete. Here, we review recent findings to present some emerging concepts on enhancer action and also outline a set of outstanding questions.

PubMed ID: 33858480 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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