Title: Prenatal PM2.5 exposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city.

Authors: Hurtado-Díaz, Magali; Riojas-Rodríguez, Horacio; Rothenberg, Stephen J; Schnaas-Arrieta, Lourdes; Kloog, Itai; Just, Allan; Hernández-Bonilla, David; Wright, Robert O; Téllez-Rojo, Martha Ma

Published In Int J Hyg Environ Health, (2021 04)

Abstract: BACKGROUND: Recent studies have reported that air pollution exposure may have neurotoxic properties. OBJECTIVE: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. METHODS: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. RESULTS: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. CONCLUSION: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.

PubMed ID: 33582606

MeSH Terms: No MeSH terms associated with this publication