Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Chromatin and transcriptional regulation by reversible RNA methylation.

Authors: Wei, Jiangbo; He, Chuan

Published In Curr Opin Cell Biol, (2021 06)

Abstract: Dynamic RNA modifications have been a burgeoning area in the last decade since the concept of 'RNA epigenetics' was proposed [1]. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. It can be installed by 'writers', removed by 'erasers,' recognized by 'readers,' and dynamically regulate the fate of methylated RNA. Until recently, the roles of reversible RNA methylation in chromatin and transcriptional regulation were not adequately studied. We discuss the new discoveries and insights into the chromatin and transcriptional regulation by m6A through two pathways: 1) effects of m6A on mRNAs encoding histone modifiers and transcriptional factors; 2) m6A regulation of chromatin-associated regulatory RNAs. Additionally, we provide an outlook on how the transcriptional regulation by RNA m6A could add an additional critical layer to transcriptional regulation.

PubMed ID: 33706173 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top