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Publication Detail

Title: Functional immune cell-astrocyte interactions.

Authors: Sanmarco, Liliana M; Polonio, Carolina M; Wheeler, Michael A; Quintana, Francisco J

Published In J Exp Med, (2021 09 06)

Abstract: Astrocytes are abundant glial cells in the central nervous system (CNS) that control multiple aspects of health and disease. Through their interactions with components of the blood-brain barrier (BBB), astrocytes not only regulate BBB function, they also sense molecules produced by peripheral immune cells, including cytokines. Here, we review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis (MS). We highlight known pathways that participate in astrocyte crosstalk with microglia, NK cells, T cells, and other cell types; their contribution to the pathogenesis of neurological diseases; and their potential value as therapeutic targets.

PubMed ID: 34292315 Exiting the NIEHS site

MeSH Terms: Astrocytes/cytology; Astrocytes/physiology*; Blood-Brain Barrier; Cell Communication; Humans; Killer Cells, Natural/immunology; Killer Cells, Natural/physiology*; Microglia/cytology*; Microglia/metabolism; Multiple Sclerosis/immunology*; Multiple Sclerosis/pathology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism

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