Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA.

Authors: Housh, Kurt; Jha, Jay S; Haldar, Tuhin; Amin, Saosan Binth Md; Islam, Tanhaul; Wallace, Amanda; Gomina, Anuoluwapo; Guo, Xu; Nel, Christopher; Wyatt, Jesse W; Gates, Kent S

Published In DNA Repair (Amst), (2021 02)

Abstract: Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to remove interstrand DNA cross-links (ICLs) from their genome but the identity of the naturally-occurring, endogenous substrates that drove the evolution and retention of these DNA repair systems across a wide range of life forms remains uncertain. In this review, we describe more than a dozen chemical processes by which endogenous ICLs plausibly can be introduced into cellular DNA. The majority involve DNA degradation processes that introduce aldehyde residues into the double helix or reactions of DNA with endogenous low molecular weight aldehyde metabolites. A smaller number of the cross-linking processes involve reactions of DNA radicals generated by oxidation.

PubMed ID: 33385969 Exiting the NIEHS site

MeSH Terms: Animals; DNA Adducts/metabolism*; DNA Repair*; Humans

Back
to Top