Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study.

Authors: Horton, Daniel B; Barrett, Emily S; Roy, Jason; Gennaro, Maria Laura; Andrews, Tracy; Greenberg, Patricia; Bruiners, Natalie; Datta, Pratik; Ukey, Rahul; Velusamy, Senthil K; Fine, Daniel; Honnen, William J; Yin, Yue Sandra; Pinter, Abraham; Brooks, Andrew; Tischfield, Jay; Hussain, Sabiha; Jagpal, Sugeet; Swaminathan, Shobha; Parmar, Veenat; Reilly, Nancy; Gaur, Sunanda; Panettieri, Reynold A; Carson, Jeffrey L; Blaser, Martin J

Published In J Infect Dis, (2021 10 28)

Abstract: BACKGROUND: We studied risk factors, antibodies, and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a diverse, ambulatory population. METHODS: A prospective cohort (n = 831) previously undiagnosed with SARS-CoV-2 infection underwent serial testing (SARS-CoV-2 polymerase chain reaction, immunoglobulin G [IgG]) for 6 months. RESULTS: Ninety-three participants (11.2%) tested SARS-CoV-2-positive: 14 (15.1%) asymptomatic, 24 (25.8%) severely symptomatic. Healthcare workers (n = 548) were more likely to become infected (14.2% vs 5.3%; adjusted odds ratio, 2.1; 95% confidence interval, 1.4-3.3) and severely symptomatic (29.5% vs 6.7%). IgG antibodies were detected after 79% of asymptomatic infections, 89% with mild-moderate symptoms, and 96% with severe symptoms. IgG trajectories after asymptomatic infections (slow increases) differed from symptomatic infections (early peaks within 2 months). Most participants (92%) had persistent IgG responses (median 171 days). In multivariable models, IgG titers were positively associated with symptom severity, certain comorbidities, and hospital work. Dyspnea and neurologic changes (including altered smell/taste) lasted ≥ 120 days in ≥ 10% of affected participants. Prolonged symptoms (frequently more severe) corresponded to higher antibody levels. CONCLUSIONS: In a prospective, ethnically diverse cohort, symptom severity correlated with the magnitude and trajectory of IgG production. Symptoms frequently persisted for many months after infection.Clinical Trials Registration. NCT04336215.

PubMed ID: 34387310 Exiting the NIEHS site

MeSH Terms: Adult; Antibodies, Viral/blood*; Antibodies, Viral/immunology; Asymptomatic Infections/epidemiology; COVID-19/blood; COVID-19/diagnosis*; COVID-19/epidemiology; COVID-19/transmission; Comorbidity; Female; Humans; Immunoglobulin G/blood*; Immunoglobulin G/immunology; Incidence; Male; Middle Aged; Prospective Studies; Risk Factors; SARS-CoV-2/immunology; SARS-CoV-2/isolation & purification*; Severity of Illness Index*; Young Adult

Back
to Top