Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children.

Authors: Zhang, Amy L; Balmes, John R; Lutzker, Liza; Mann, Jennifer K; Margolis, Helene G; Tyner, Tim; Holland, Nina; Noth, Elizabeth M; Lurmann, Fred; Hammond, S Katharine; Holm, Stephanie M

Published In J Expo Sci Environ Epidemiol, (2022 Jul)

Abstract: BACKGROUND: Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children. OBJECTIVE: This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children. METHODS: We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO2), nitrogen oxides (NOx), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM2.5)) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)). RESULTS: HDL cholesterol showed an inverse association with NO2 and NOx, with the strongest relationship between HDL and 3-month exposure to NO2 (-15.4 mg/dL per IQR increase in 3-month NO2, 95% CI = -27.4, -3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames. CONCLUSION: Our results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood.

PubMed ID: 34417545 Exiting the NIEHS site

MeSH Terms: Air Pollutants*/adverse effects; Air Pollutants*/analysis; Air Pollution*/adverse effects; Air Pollution*/analysis; Biomarkers/analysis; Child; Cholesterol, HDL/analysis; Cross-Sectional Studies; Environmental Exposure/adverse effects; Environmental Exposure/analysis; Glycated Hemoglobin/analysis; Humans; Nitrogen Dioxide/analysis; Oxidative Stress; Particulate Matter/adverse effects; Particulate Matter/analysis; Uteroglobin/analysis; Vehicle Emissions/analysis

Back
to Top