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Publication Detail

Title: The Endocannabinoid System in Caenorhabditis elegans.

Authors: Estrada-Valencia, Rubén; de Lima, María Eduarda; Colonnello, Aline; Rangel-López, Edgar; Saraiva, Nariani Rocha; de Ávila, Daiana Silva; Aschner, Michael; Santamaría, Abel

Published In Rev Physiol Biochem Pharmacol, (2021 Aug 17)

Abstract: The existence of a formal Endocannabinoid System in C. elegans has been questioned due to data showing the absence of typical cannabinoid receptors in the worm; however, the presence of a full metabolism for endocannabinoids, alternative ligands, and receptors for these agents and a considerable number of orthologous and homologous genes regulating physiological cannabinoid-like signals and responses - several of which are similar to those of mammals - demonstrates a well-structured and functional complex system in nematodes. In this review, we describe and compare similarities and differences between the Endocannabinoid System in mammals and nematodes, highlighting the basis for the integral study of this novel system in the worm.

PubMed ID: 34401955 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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