Title: Polychlorinated Biphenyls and Nonalcoholic Fatty Liver Disease.

Authors: Wahlang, Banrida; Hardesty, Josiah E; Jin, Jian; Falkner, K Cameron; Cave, Matthew C

Published In Curr Opin Toxicol, (2019 Apr)

Abstract: Polychlorinated biphenyls (PCBs) have been associated with abnormal liver enzymes and suspected nonalcoholic fatty liver disease (NAFLD) in cohort studies. NAFLD affects greater than 25% of the global population and may result in liver-related mortality. Both dioxin-like and non-dioxin-like PCBs have been associated with NAFLD, but their effects and mechanisms differ. Dioxin-like PCBs altered the gut:liver axis and microbiome and caused hepatic steatosis by disrupting hepatic lipid metabolism. In contrast, NDL PCBs reduced the liver's protective responses to promote diet-induced NAFLD. Mechanisms included the disruption of phosphoprotein signaling resulting in altered nuclear receptor function.

PubMed ID: 34485777

MeSH Terms: No MeSH terms associated with this publication