Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans.

Authors: Bigdeli, Tim B; Fanous, Ayman H; Li, Yuli; Rajeevan, Nallakkandi; Sayward, Frederick; Genovese, Giulio; Gupta, Rishab; Radhakrishnan, Krishnan; Malhotra, Anil K; Sun, Ning; Lu, Qiongshi; Hu, Yiming; Li, Boyang; Chen, Quan; Mane, Shrikant; Miller, Perry; Cheung, Kei-Hoi; Gur, Raquel E; Greenwood, Tiffany A; Braff, David L; Consortium on the Genetics of Schizophrenia (COGS); Achtyes, Eric D; Buckley, Peter F; Escamilla, Michael A; Lehrer, Douglas; Malaspina, Dolores P; McCarroll, Steven A; Rapaport, Mark H; Vawter, Marquis P; Pato, Michele T; Pato, Carlos N; Genomic Psychiatry Cohort (GPC) Investigators; Zhao, Hongyu; Kosten, Thomas R; Brophy, Mary; Pyarajan, Saiju; Shi, Yunling; O'Leary, Timothy J; Gleason, Theresa; Przygodzki, Ronald; Muralidhar, Sumitra; Gaziano, J Michael; Million Veteran Program (MVP); Huang, Grant D; Concato, John; Siever, Larry J; Aslan, Mihaela; Harvey, Philip D

Published In Schizophr Bull, (2021 Mar 16)

Abstract: BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing the major impact of these psychiatric disorders on the psychosocial function of more than 200 000 US Veterans, the Department of Veterans Affairs (VA) recently completed genotyping of more than 8000 veterans with SCZ and BIP in the Cooperative Studies Program (CSP) #572. METHODS: We performed genome-wide association studies (GWAS) in CSP #572 and benchmarked the predictive value of polygenic risk scores (PRS) constructed from published findings. We combined our results with available summary statistics from several recent GWAS, realizing the largest and most diverse studies of these disorders to date. RESULTS: Our primary GWAS uncovered new associations between CHD7 variants and SCZ, and novel BIP associations with variants in Sortilin Related VPS10 Domain Containing Receptor 3 (SORCS3) and downstream of PCDH11X. Combining our results with published summary statistics for SCZ yielded 39 novel susceptibility loci including CRHR1, and we identified 10 additional findings for BIP (28 326 cases and 90 570 controls). PRS trained on published GWAS were significantly associated with case-control status among European American (P < 10-30) and African American (P < .0005) participants in CSP #572. CONCLUSIONS: We have demonstrated that published findings for SCZ and BIP are robustly generalizable to a diverse cohort of US veterans. Leveraging available summary statistics from GWAS of global populations, we report 52 new susceptibility loci and improved fine-mapping resolution for dozens of previously reported associations.

PubMed ID: 33169155 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top