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Title: Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study.

Authors: Buckley, Jessie P; Kuiper, Jordan R; Lanphear, Bruce P; Calafat, Antonia M; Cecil, Kim M; Chen, Aimin; Xu, Yingying; Yolton, Kimberly; Kalkwarf, Heidi J; Braun, Joseph M

Published In Environ Health Perspect, (2021 Sep)

Abstract: BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) may impair bone accrual and strength via endocrine disruption and nuclear receptor agonism, but human studies are primarily of adults or cross-sectional. OBJECTIVES: We assessed associations of individual PFAS and their mixture during pregnancy with child bone mineral content (BMC) and areal bone mineral density (aBMD) at age 12 y. METHODS: Among 206 mother-child pairs enrolled in a prospective cohort (2003-2006), we quantified perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in maternal serum collected during gestation or delivery. When children were age 12 y, we performed dual energy X-ray absorptiometry and calculated BMC, aBMD, and bone mineral apparent density (BMAD) RESULTS: In covariate-adjusted models, we found that higher maternal serum concentrations of PFOA, PFNA, and the PFAS mixture were associated with lower total hip and forearm (one-third distal radius) BMC DISCUSSION: Maternal PFAS concentrations during pregnancy may be associated with lower bone mineral accrual and strength in early adolescence.

PubMed ID: 34585601 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Alkanesulfonic Acids*; Bayes Theorem; Bone Density; Child; Cross-Sectional Studies; Environmental Pollutants*; Female; Fluorocarbons*; Humans; Male; Outcome Assessment, Health Care; Pregnancy; Prospective Studies

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