Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19.

Authors: Le, Trang T; Gutiérrez-Sacristán, Alba; Son, Jiyeon; Hong, Chuan; South, Andrew M; Beaulieu-Jones, Brett K; Loh, Ne Hooi Will; Luo, Yuan; Morris, Michele; Ngiam, Kee Yuan; Patel, Lav P; Samayamuthu, Malarkodi J; Schriver, Emily; Tan, Amelia L M; Moore, Jason; Cai, Tianxi; Omenn, Gilbert S; Avillach, Paul; Kohane, Isaac S; Consortium for Clinical Characterization of COVID-19 by EHR (4CE); Visweswaran, Shyam; Mowery, Danielle L; Xia, Zongqi

Published In Sci Rep, (2021 Oct 12)

Abstract: Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January-September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7-7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7-10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19-25%), cerebrovascular diseases (24%, 13-35%), nontraumatic intracranial hemorrhage (34%, 20-50%), encephalitis and/or myelitis (37%, 17-60%) and myopathy (72%, 67-77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.

PubMed ID: 34642371 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top