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Your Environment. Your Health.

Publication Detail

Title: Short-term air pollution, cognitive performance, and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study.

Authors: Gao, Xu; Coull, Brent; Lin, Xihong; Vokonas, Pantel; Spiro 3rd, Avron; Hou, Lifang; Schwartz, Joel; Baccarelli, Andrea A

Published In Nat Aging, (2021 May)

Abstract: Air pollution, especially the fine particulate matter (PM2.5), may impair cognitive performance1-3, but its short-term impact remains poorly understood. We investigated the short-term associations of PM2.5 with the cognitive performances of 954 white males measured as the global cognitive function (GCF) and Mini-Mental State Examination (MMSE) scores, and further explored whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) could modify their relationships. Higher short-term exposure to PM2.5 demonstrated non-linear negative associations with cognitive function. Compared with the lowest quartile of the 28-day average PM2.5 concentration, the 2nd, 3rd, and 4th quartiles were associated with 0.378-, 0.376-, and 0.499-unit decreases in GCF score, 0.484-, 0.315-, and 0.414-unit decreases in MMSE score, and 69%, 45%, and 63% greater odds of low MMSE scores (≤25), respectively. Such adverse effects were attenuated among NSAIDs users compared to non-users. This study elucidates the short-term impacts of air pollution on cognition and warrants further investigations on the modifying effects of NSAIDs.

PubMed ID: 34841262 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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