Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Short-term air pollution, cognitive performance, and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study.

Authors: Gao, Xu; Coull, Brent; Lin, Xihong; Vokonas, Pantel; Spiro 3rd, Avron; Hou, Lifang; Schwartz, Joel; Baccarelli, Andrea A

Published In Nat Aging, (2021 May)

Abstract: Air pollution, especially the fine particulate matter (PM2.5), may impair cognitive performance1-3, but its short-term impact remains poorly understood. We investigated the short-term associations of PM2.5 with the cognitive performances of 954 white males measured as the global cognitive function (GCF) and Mini-Mental State Examination (MMSE) scores, and further explored whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) could modify their relationships. Higher short-term exposure to PM2.5 demonstrated non-linear negative associations with cognitive function. Compared with the lowest quartile of the 28-day average PM2.5 concentration, the 2nd, 3rd, and 4th quartiles were associated with 0.378-, 0.376-, and 0.499-unit decreases in GCF score, 0.484-, 0.315-, and 0.414-unit decreases in MMSE score, and 69%, 45%, and 63% greater odds of low MMSE scores (≤25), respectively. Such adverse effects were attenuated among NSAIDs users compared to non-users. This study elucidates the short-term impacts of air pollution on cognition and warrants further investigations on the modifying effects of NSAIDs.

PubMed ID: 34841262 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

to Top