Title: Prenatal Exposure to Disinfection Byproducts and Intrauterine Growth in a Chinese Cohort.

Authors: Liu, Chong; Sun, Yang; Mustieles, Vicente; Chen, Ying-Jun; Huang, Li-Li; Deng, Yan-Ling; Wang, Yi-Xin; Lu, Wen-Qing; Messerlian, Carmen

Published In Environ Sci Technol, (2021 Dec 07)

Abstract: Disinfection byproduct (DBP) exposure has been associated with birth size, pregnancy oxidative stress, and other adverse perinatal outcomes. However, little is known about the potential effect of prenatal DBP exposure on intrauterine growth. The present study included 1516 pregnant women from the Xiaogan Disinfection By-Products (XGDBP) birth cohort who were measured for four blood trihalomethanes [i.e., chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and two urinary haloacetic acids [i.e., dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)] across pregnancy trimesters. Second- and third-trimester fetal ultrasound measures of the abdominal circumference (AC), head circumference, biparietal diameter, femur length, and estimated fetal weight and birth weight were converted into z-scores. After adjusting for potential confounders, linear mixed models showed a decreasing AC z-score across tertiles of blood brominated THM (Br-THMs, the sum of BDCM, DBCM, and TBM) and total THM (THM4, the sum of Br-THMs and TCM) concentrations (both p for trend <0.01). We also observed a decreasing AC z-score across categories of blood TBM during pregnancy trimesters (p for trend = 0.03). Urinary haloacetic acids were unrelated to fetal growth parameters. In summary, prenatal exposure to THMs, particularly during the first trimester, was associated with reduced fetal abdominal circumference.

PubMed ID: 34813313

MeSH Terms: Birth Cohort; China; Disinfection; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects*; Trichloroacetic Acid; Trihalomethanes/toxicity; Water Pollutants, Chemical*