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National Institute of Environmental Health Sciences

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Publication Detail

Title: Inhibition of gap junctional intercellular communication in rat liver epithelial cells with transforming RNA.

Authors: Hayashi, T; Trosko, J E; Hamada, K

Published In FEBS Lett, (2001 Mar 02)

Abstract: Previous studies indicated that transforming RNA, derived from the 3' half of the U5 small nuclear RNA first stem structure, suppressed the secretory protein translation in vitro. Gap junctions facilitate homeostatic control of cell growth and differentiation and their dysfunction has been correlated with carcinogenesis. Here, we reported that transforming RNA directly suppressed the gap junction protein, connexin 43, translation and thereby inhibited functional gap junction function in rat epithelial cells. Together with previous data, this implies that altered expression of transforming RNA itself is a potential mechanism in inhibiting gap junction function during carcinogenesis.

PubMed ID: 11240127 Exiting the NIEHS site

MeSH Terms: Animals; Blotting, Western; Cell Communication/drug effects; Cell Communication/physiology*; Cell Transformation, Neoplastic/metabolism; Connexin 43/antagonists & inhibitors; Connexin 43/biosynthesis; Connexin 43/genetics; Epithelial Cells/cytology; Epithelial Cells/drug effects; Epithelial Cells/metabolism*; Gap Junctions/drug effects; Gap Junctions/metabolism*; Liver/cytology; Liver/metabolism*; Nucleic Acid Conformation; Protein Biosynthesis/drug effects; RNA, Small Nuclear/genetics; RNA, Small Nuclear/metabolism*; RNA, Small Nuclear/pharmacology; Rats; Transfection

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