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Publication Detail

Title: MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum.

Authors: Xiong, Aoli; Kaushal, Simran; Tay, Ian Junjie; Engelward, Bevin P; Han, Jongyoon; Preiser, Peter R

Published In STAR Protoc, (2021 09 17)

Abstract: Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based on the same principle as the comet assay but provides greater efficacy, automated data processing, and improved consistency between experiments. In this protocol, we present MalariaCometChip to quantitatively assess drug-induced DNA damage in Plasmodium falciparum. For complete details on the use and execution of this protocol, please refer to Xiong et al. (2020).

PubMed ID: 34527954 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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