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National Institute of Environmental Health Sciences

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Publication Detail

Title: Multiple mutations and cancer.

Authors: Loeb, Lawrence A; Loeb, Keith R; Anderson, Jon P

Published In Proc Natl Acad Sci U S A, (2003 Feb 04)

Abstract: Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype hypothesis for the prognosis, treatment, and prevention of human cancers.

PubMed ID: 12552134 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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