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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.

Authors: Hedberg, Matthew L; Berry, Corbett T; Moshiri, Ata S; Xiang, Yan; Yeh, Christopher J; Attilasoy, Cem; Capell, Brian C; Seykora, John T

Published In Int J Mol Sci, (2022 Mar 23)

Abstract: Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

PubMed ID: 35408839 Exiting the NIEHS site

MeSH Terms: Carcinoma, Basal Cell*; Carcinoma, Squamous Cell*/epidemiology; Carcinoma, Squamous Cell*/genetics; Humans; Incidence; Skin Neoplasms*/pathology; United States

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