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Publication Detail

Title: Genome-wide Excision Repair Map of Cyclobutane Pyrimidine Dimers in Arabidopsis and the Roles of CSA1 and CSA2 Proteins in Transcription-coupled Repair.

Authors: Kaya, Sezgi; Adebali, Ogun; Oztas, Onur; Sancar, Aziz

Published In Photochem Photobiol, (2022 05)

Abstract: Plants depend on light for energy production. However, the UV component in sunlight also inflicts DNA damage, mostly in the form of cyclobutane pyrimidine dimers (CPD) and (6-4) pyrimidine-pyrimidone photoproducts, which are mutagenic and lethal to the plant cells. These lesions are repaired by blue-light-dependent photolyases and the nucleotide excision repair enzymatic systems. Here, we characterize nucleotide excision repair in Arabidopsis thaliana genome-wide and at single nucleotide resolution with special focus on transcription-coupled repair and the role of the CSA1 and CSA2 genes/proteins in dictating the efficiency and the strand preference of repair of transcribed genes. We demonstrate that CSA1 is the dominant protein in coupling repair to transcription with minor contribution from CSA2.

PubMed ID: 34525225 Exiting the NIEHS site

MeSH Terms: Arabidopsis*/genetics; Arabidopsis*/metabolism; DNA Damage; DNA Repair; Deoxyribodipyrimidine Photo-Lyase*/genetics; Deoxyribodipyrimidine Photo-Lyase*/metabolism; Pyrimidine Dimers/metabolism; Ultraviolet Rays

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