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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Integrated Framework for Identifying Toxic Transformation Products in Complex Environmental Mixtures.

Authors: Chibwe, Leah; Titaley, Ivan A; Hoh, Eunha; Massey Simonich, Staci L

Published In Environ Sci Technol Lett, (2017 Feb 14)

Abstract: Complex environmental mixtures consist of hundreds to thousands of unknown and unregulated organic compounds that may have toxicological relevance, including transformation products (TPs) of anthropogenic organic pollutants. Non-targeted analysis and suspect screening analysis offer analytical approaches for potentially identifying these toxic transformation products. However, additional tools and strategies are needed in order to reduce the number of chemicals of interest and focus analytical efforts on chemicals that may pose risks to humans and the environment. This brief review highlights recent developments in this field and suggests an integrated framework that incorporates complementary instrumental techniques, computational chemistry, and toxicity analysis, for prioritizing and identifying toxic TPs in the environment.

PubMed ID: 35600207 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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