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Title: Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.

Authors: Carey, Meghan E; Rando, Juliette; Melnyk, Stepan; James, S Jill; Snyder, Nathaniel; Salafia, Carolyn; Croen, Lisa A; Fallin, M Daniele; Hertz-Picciotto, Irva; Volk, Heather; Newschaffer, Craig; Lyall, Kristen

Published In J Autism Dev Disord, (2023 Aug)

Abstract: We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.

PubMed ID: 35678944 Exiting the NIEHS site

MeSH Terms: Autism Spectrum Disorder*/complications; Autism Spectrum Disorder*/diagnosis; Biomarkers; Child; Female; Glutathione Disulfide; Glutathione/metabolism; Humans; Oxidative Stress; Pregnancy; Vitamins

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