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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.

Authors: Liu, Geoffrey; Zhou, Wei; Wang, Lisa I; Park, Sohee; Miller, David P; Xu, Li Lian; Wain, John C; Lynch, Thomas J; Su, Li; Christiani, David C

Published In Cancer Lett, (2004 Oct 8)

Abstract: Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism. In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we evaluated whether the MPO -G463A polymorphism (associated with a novel estrogen receptor binding site) modifies the association between the SOD2 Ala16Val polymorphism and NSCLC risk differently by gender. For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype.

PubMed ID: 15331175 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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