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Publication Detail

Title: Regulation of beta-adrenergic responses in airway smooth muscle.

Authors: Shore, Stephanie A; Moore, Paul E

Published In Respir Physiol Neurobiol, (2003 Sep 16)

Abstract: Decreased responsiveness to beta-adrenergic receptor agonists is a characteristic feature of human asthma. This review summarizes data regarding the impact of chronic beta agonist stimulation, cytokines, prostanoids and other factors on beta-adrenergic responses in human airway smooth muscle, as well as the impact of polymorphisms of the beta(2)-adrenergic receptor on these responses. Effects of beta-agonists on both airway smooth muscle relaxation and gene expression are considered. Understanding the regulation of beta-adrenergic responses in airway smooth muscle cells may prove to be an important step in improving the efficacy of beta-agonists for the treatment of asthma.

PubMed ID: 14516725 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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