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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles.

Authors: Arredouani, Mohamed S; Yang, Zhiping; Imrich, Amy; Ning, Yaoyu; Qin, Guozhong; Kobzik, Lester

Published In Am J Respir Cell Mol Biol, (2006 Oct)

Abstract: The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied. We used mice genetically deficient in SR-AI/II and their wild-type C57BL/6 counterparts to investigate the contribution of this receptor to defense against pneumococcal infection and inhaled particles. SR-AI/II deficiency caused impaired phagocytosis of fluorescent bacteria in vivo, diminished clearance of live bacteria from the lungs, and substantially increased pneumonic inflammation. Survival studies also showed increased mortality in SR-AI/II-deficient mice with pneumococcal lung infection. Similarly, after challenge of the airways with TiO(2) particles, SR-AI/II-deficient mice showed increased proinflammatory cytokine levels in lung lavage fluid and a more pronounced neutrophilic inflammation. The data indicate that the lung macrophage class A scavenger receptor SR-AI/II contributes to innate defense against bacteria and inhaled particles.

PubMed ID: 16675784 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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