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Publication Detail

Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.

Authors: Trujillo, K M; Yuan, S S; Lee, E Y; Sung, P

Published In J Biol Chem, (1998 Aug 21)

Abstract: Genetic studies in yeast have indicated a role of the RAD50 and MRE11 genes in homologous recombination, telomere length maintenance, and DNA repair processes. Here, we purify from nuclear extract of Raji cells a complex consisting of human Rad50, Mre11, and another protein factor with a size of about 95 kDa (p95), which is likely to be Nibrin, the protein encoded by the gene mutated in Nijmegen breakage syndrome. We show that the Rad50-Mre11-p95 complex possesses manganese-dependent single-stranded DNA endonuclease and 3' to 5' exonuclease activities. These nuclease activities are likely to be important for recombination, repair, and genomic stability.

PubMed ID: 9705271 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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