Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Synthesis of the N2-deoxyguanosine adduct of the potent dietary mutagen IQ.

Authors: Stover, James S; Rizzo, Carmelo J

Published In Org Lett, (2004 Dec 23)

Abstract: [structure: see text] After bioactivation, the potent dietary mutagen 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) reacts with DNA to give two regioisomeric adducts of deoxyguanosine. The synthesis of the minor N2-adduct has been achieved utilizing the Buchwald-Hartwig palladium-catalyzed N-arylation reaction as the key step.

PubMed ID: 15606116 Exiting the NIEHS site

MeSH Terms: Alkylation; Catalysis; Deoxyguanosine/chemical synthesis*; Deoxyguanosine/chemistry; Molecular Structure; Palladium/chemistry; Quinolines/chemistry*

Back
to Top